YEARS

YEARS · Pulmonary embolism

Principle

Compare D-dimer with the YEARS threshold determined by three independently assessed clinical criteria.

Scope

Suspected acute PE in adults excluding pregnancy. Restricted to a clinically stable context and a highly sensitive quantitative FEU assay; do not use to delay management of instability. No age-adjusted threshold or pregnancy-adapted YEARS.

Interpretation limits

The entered value is compared before any rounding. The result describes the rule; it is not a standalone diagnosis.

Formula and logic

No YEARS criterion: D-dimer <1000 ng/mL FEU. At least one criterion: <500 ng/mL FEU. A value equal to the threshold does not meet the exclusion rule.

Interpretation

YEARS exclusion threshold met

The YEARS rule allows consideration of excluding PE without CT pulmonary angiography if its conditions of use are met. Verify context and assay method.

PE not excluded by YEARS

The YEARS threshold is not met: continue diagnostic assessment according to context. Elevated D-dimer does not confirm PE.

Definition version : 1.0.0

Sources

• van der Hulle et al. · Lancet — Simplified diagnostic management of suspected pulmonary embolism (the YEARS study)

  2017 · Methods and Figure 1: three criteria, strict thresholds 500/1000 ng/mL; explicit cohort exclusions.

• Siemens Healthineers — INNOVANCE D-Dimer · Instructions for Use · Rev.11

  2024-04 · FEU units p 6: 1 mg/L=1000 ng/mL=1000 µg/L. Conversion source, without dependency or manufacturer connection.